Science and Studies
History - Frieman, father of LLLT
History, Mechanism, Dose, Mitochondrial, Anti-inflammatory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/
History, Mechanism, Dose, Mitochondrial, Anti-inflammatory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/
Visible Light therapy vs. Near Infrared Light therapy
https://www.mamanatural.com/near-infrared-sauna/
History, Mechanism, Dose, Mitochondrial, Antinflammatory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/
Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/
Artificial Light and Cancer - Mal Illumination
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/
Artificial Light and Obesity
https://www.nature.com/articles/ijo2015255
https://academic.oup.com/aje/article/180/3/245/2739112
Light at night clock and metabolism
https://academic.oup.com/edrv/article/35/4/648/2354673
History, Mechanism, Dose, Mitochondrial, Antinflammatory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/
Diabetic Neuropathy
https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-_MIRE
Hair Loss
https://www.aad.org/media/stats/conditions/skin-conditions-by-the-numbers
https://www.ncbi.nlm.nih.gov/pubmed/23970445
Wound Healing, dairy cattle, cat tongue
https://www.ncbi.nlm.nih.gov/pubmed/9068161
https://pdfs.semanticscholar.org/7762/57f1debd12c652310bd11d8d53cfc5052c61.pdf
https://www.researchgate.net/publication/312142584_The_photobiomodulation_effect_of_higher-fluence_808- nm_laser_therapy_with_a_flattop_handpiece_on_the_wound_healing_of_the_earthworm_Dendrobaena_veneta_a_brief_report
Wound healing LED shows significant speed of recovery with 633nm
https://www.ncbi.nlm.nih.gov/pubmed/16581685
Scarring
https://www.ncbi.nlm.nih.gov/pubmed/26741110
Dermal Abrasions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/
Stroke
https://www.ncbi.nlm.nih.gov/pubmed/27345389
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/
https://www.ncbi.nlm.nih.gov/pubmed/17463313/
https://www.ncbi.nlm.nih.gov/pubmed/17678491/
Osteoporosis
https://www.ncbi.nlm.nih.gov/pubmed/28846932
Transcranial effect of LED
https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain
Brain Injury
https://www.researchgate.net/publication/229161498_Transcranial_low_level_laser_light_therapy_for_traumatic_brain_injury
https://www.ncbi.nlm.nih.gov/pubmed/17439348
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/
https://www.ncbi.nlm.nih.gov/pubmed/11059663
Sleep
https://www.ncbi.nlm.nih.gov/pubmed/12811613
Testosterone replacement
http://connection.ebscohost.com/c/articles/96971683/effects-low-level-laser-therapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats
Headache Light therapy modulates serotonin levels and blood flow in women with headache. A preliminary study.
https://www.ncbi.nlm.nih.gov/pubmed/26202374
Dermal Abrasions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/
Tendonitis
https://www.ncbi.nlm.nih.gov/pubmed/226734405
Fibromayalgia
https://www.ncbi.nlm.nih.gov/pubmed/24801056
Effectiveness of low-level laser therapy on pain intensity, pressure pain threshold, and SF-MPQ indexes of women with myofascial pain. :10.11607/ofph.2032. Epub 2018 Apr 25.
Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis.
https://www.ncbi.nlm.nih.gov/pubmed/29697718
Acne
https://www.ncbi.nlm.nih.gov/pubmed/16468292
38. https://www.ncbi.nlm.nih.gov/pubmed/28232927
Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.
https://www.ncbi.nlm.nih.gov/pubmed/22615511
Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/
Depression Long term study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556873/
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
https://www.ncbi.nlm.nih.gov/pubmed/19995444
Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.
https://www.ncbi.nlm.nih.gov/pubmed/27267860
Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.
https://www.ncbi.nlm.nih.gov/pubmed/27379735
Dementia
Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017;35(8):432-441
https://www.ncbi.nlm.nih.gov/pubmed/28186867dementia, memory, mood
General Brain Health & Cognitive Performance.
Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.
https://www.ncbi.nlm.nih.gov/pubmed/23200785
Shining light on the head: Photobiomodulation for brain disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/
Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/
Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777909/
Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light
https://www.sciencedirect.com/science/article/pii/S1074742707001153
Improving executive function using transcranial infrared laser stimulation.
https://www.ncbi.nlm.nih.gov/pubmed/26017772
https://www.ncbi.nlm.nih.gov/pubmed/26535475
Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.
https://www.ncbi.nlm.nih.gov/pubmed/27220529
Neurological and psychological applications of transcranial lasers and LEDs.
https://www.ncbi.nlm.nih.gov/pubmed/23806754
Alzheimers Disease
Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease
https://www.researchgate.net/publication/263742704_Low- Level_Laser_Therapy_Ameliorates_Disease_Progression_in_a_Mouse_Model_of_Alzheimer's_Disease
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.
https://www.ncbi.nlm.nih.gov/pubmed/24387311
Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.
https://www.ncbi.nlm.nih.gov/pubmed/23946409
Bipolar
Is bipolar disorder an inflammatory condition? The relevance of microglial activation.
https://www.ncbi.nlm.nih.gov/pubmed/23196997
Arthritis
mice subjected to acute arthritis condition.
https://www.ncbi.nlm.nih.gov/pubmed/28772237
Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.
https://www.ncbi.nlm.nih.gov/pubmed/24028507
Bell's Palsy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322014/
Testosterone
The effects of low level laser therapy (LLLT) on the testis in elevating serum testosterone level in rats
http://connection.ebscohost.com/c/articles/96971683/effects-low-level-lasertherapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats
Aging Skin
Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single- Blinded Study
https://www.sciencedirect.com/science/article/pii/S0022202X15341749
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/
ORAL HEALTH
Low Level Laser Therapy: A Panacea for oral maladies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639680/
NUTS AND BOLTS OF LLLT - Survey of Basically Everything treated by LLLT
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/
MECHANISM OF ACTION OF LLLT - dose, etc. Biphasic Dose Response in Low Level Light
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790317/
The role of nitric oxide in low level light therapy
https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapyHow Mitochondria absorb visible light
https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy
REVERSAL OF AGING USING RED LIGHT AND NEAR-INFRARED LIGHT THERAPY
A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.
https://www.ncbi.nlm.nih.gov/pubmed/24286286
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332991/
ELIMINATION OF FAT
Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheeks Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.
https://www.ncbi.nlm.nih.gov/pubmed/24049929
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/
“Overweight and obesity.” Centers for Disease Control and Prevention (2007). Available
Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/
Sene-fiorense M, Duarte FO, De aquino junior, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Sung Med. 2015;47(7):634-42
https://www.cdc.gov/onsidty/data/ad/ult.html
Ger Med Sci. 2006 Jul 11:4; Doc05. Influence of water-filtered infrared-A (wiRA) on reduction of local fat and body weight by physical exercise. Mockel F, Hoffman G, Obermuller R, Drobnik W,Schmitz G.
https://www.ncbi.nlm.nih.gov/pubmed/26220050
Mcrae E, Boris J. Independent evaluation of low-level laser therapy 635nm for non-invasive body contouring of the waist, hips and thighs. Lasers Surg Med. 2013;45(1):1-7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703221/
635nm - 660nm for Fat Loss
https://www.ncbi.nlm.nih.gov/pubmed/23355338
Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225499/
Li, Y., Park, JS., Deng, JH. Et al. Cytochrome c oxidase subunit IV is useful for assembly and respiratory function of the enzyme complex. J Bioenerg, Biomember (2006)38;283
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/
Brown GC, Borutalite V. Nitric Oxide, cytochrome c, and mitochondria. Biochem Soc. Symp. 1999:66;17-25
https://www.ncbi.nlm.nih.gov/pubmed/10989653
LIGHT MEDICINE AND ANIMALS
Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.
https://www.ncbi.nlm.nih.gov/pubmed/21356170
Inflammation in general
Mechanisms and applications of the anti-inflammatory effects of photobiomodulation
https://www.ncbi.nlm.nih.gov/pubmed/28748217
Veterinary Medicine and Photobiomodulation
http://veterinarymedicine.dvm360.com/photobiomodulation-facts-and-functions-veterinary-rehab
An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113823/
EYE HEALTH AND WOUND HEALING
https://www.ncbi.nlm.nih.gov/pubmed/26427443
Photobiomodulation for the treatment of retinal diseases: a review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/
Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration
https://www.ncbi.nlm.nih.gov/pubmed/11845369
https://www.ncbi.nlm.nih.gov/pubmed/16120414
Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy.
Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats.
https://www.ncbi.nlm.nih.gov/pubmed/24551842/
Viral Warts
https://www.researchgate.net/publication/269749233_PULSED_DYE_LASER_TREATMENT_FOR_RECALCITRANT_VIRAL_WARTS_AUTO-SIMULTANEOUS_LASER_TREATMENT
Plantar Warts
https://www.ncbi.nlm.nih.gov/pubmed/16942430?dopt=Citation
Dermatitis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/
Psoriasis
https://www.researchgate.net/publication/320600622_A_clinical_review_of_phototherapy_for_psoriasis
Improved Sleep & PTSD
https://www.ncbi.nlm.nih.gov/pubmed/24568233
Thyroid Tissue Generation
https://www.ncbi.nlm.nih.gov/pubmed/22718472
https://thyroidpharmacist.com/articles/lasers-thyroid-tissue-regeneration/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534372/
https://www.ncbi.nlm.nih.gov/pubmed/20662037
Muscle Performance and Recovery Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training
https://www.researchgate.net/publication/269412590_Effect_of_low-level_laser_therapy_on_muscle_adaptation_to_knee_extensor_eccentric_training
Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light.
Cleber Ferraresi et al. 2012
https://www.ncbi.nlm.nih.gov/pubmed/23626925
Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review. Paul A Borsa et al. 2013
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554033/Verifies the benefit of LLLT in all phases of muscle recovery: 107
https://www.unip.br/presencial/comunicacao/publicacoes/ics/edicoes/2010/03_jul-set/V28_n3_2010_p286-288.pdf
Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.
https://www.ncbi.nlm.nih.gov/pubmed/29090398
Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study. Pinto HD et al. 2016
https://www.ncbi.nlm.nih.gov/pubmed/27050245
Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Ferraresi C et al. 2016
https://www.ncbi.nlm.nih.gov/pubmed/25378263
Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed- Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Ferraresi C et al. 2016
https://www.ncbi.nlm.nih.gov/pubmed/27088469
Diabetic Neuropathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639677/
https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-
_MIRE
Bells Palsy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838725/
http://www.litecure.com/wp-content/uploads/2016/09/Laser-Bells-Palsy.pdf
https://www.researchgate.net/publication/271346875_Helium_neon_and_diode_laser_therapy_is_an_effective_adjunctive_therapy_for_facial_paralysis